STUDY ON OPTIMAL DESIGN OF MISTUNED BLADED DISK

Study on optimal design of mistuned bladed disk

Although, in designing blades, it is assumed that all blades on a disk are identical (tuned system), the vibration characteristics of the blade is slightly different due to the manufacturing tolerance, the deviation of the material property, and so on (mistuned system).As a result, in the forced response of an actual bladed disk caused by the flow

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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism

Abstract Microglia dysfunction is implicated in several neurodegenerative disorders, including a rare microgliopathy; CSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (CSF1R-ALSP).CSF1R-ALSP is caused by heterozygous loss-of-function mutations in the colony stimulating factor 1 receptor (CSF1R) gene, which enco

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